Xpo5 | exportin 5
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Reproductive system Immune system Integument Endocrine/exocrine gland Embryo Growth/size/body region Nervous system Vision/eye Hematopoietic system Cardiovascular system Mortality/aging
11 No significant impact
2 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal ovary morphology | 1 supporting dataset | Xpo5em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| enlarged ovary | 1 supporting dataset | Xpo5em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| spina bifida | 1 supporting dataset | Xpo5em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Xpo5em1(IMPC)Mbp | heterozygote | Late adult | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Xpo5em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Xpo5em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Xpo5em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Xpo5em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Xpo5em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Xpo5em1(IMPC)Mbp | heterozygote | Late adult | N/A * |
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Human diseases caused by Xpo5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Xpo5.
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| Xpo5em1(IMPC)Mbp | Exon Deletion | | mouse |
| Xpo5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Xpo5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |