Lamtor1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Reproductive system Endocrine/exocrine gland Growth/size/body region Mortality/aging
16 No significant impact
4 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
29Embryo tissues
| abnormal testis morphology | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| enlarged testis | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Lamtor1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal ovary morphology | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| enlarged ovary | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| abnormal epididymis morphology | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * | ||
| enlarged epididymis | 1 supporting dataset | Lamtor1tm1b(KOMP)Wtsi | heterozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (1/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Lamtor1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Lamtor1.
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| Lamtor1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Lamtor1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Lamtor1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |