Tnfaip8l1 | tumor necrosis factor, alpha-induced protein 8-like 1
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Immune system Integument Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
11 No significant impact
4 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| small spleen | 1 supporting dataset | Tnfaip8l1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Tnfaip8l1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| small liver | 1 supporting dataset | Tnfaip8l1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal liver morphology | 2 supporting datasets | Tnfaip8l1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Tnfaip8l1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Tnfaip8l1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged liver | 1 supporting dataset | Tnfaip8l1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Tnfaip8l1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Tnfaip8l1em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Tnfaip8l1em1(IMPC)Mbp | homozygote | Late adult | N/A * |
| | | | | | | | | | |
Human diseases caused by Tnfaip8l1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Tnfaip8l1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Tnfaip8l1em1(IMPC)Mbp | Whole-gene deletion | | mouse |
| Tnfaip8l1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Tnfaip8l1tm96610(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Tnfaip8l1tm96610(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |