Asf1a | anti-silencing function 1A histone chaperone
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging
13 No significant impact
5 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| abnormal embryo turning | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | heterozygote | Early adult | 2.35x10-8 | ||
| abnormal neural tube closure | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | heterozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Asf1atm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Asf1a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Asf1a.
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| Asf1atm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Asf1atm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |