Nop10 | NOP10 ribonucleoprotein

GeneMGI:1913431Synonyms: H/ACA small nucleolar RNPs, Nola3, +2 more

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

16 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

4Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to organogenesis	1 supporting dataset	Nop10^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Nop10^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.03x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Nop10^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nop10.

Associated images

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Histopathology

There is no histopathology data found for Nop10.

IMPC related publications

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External links

No external links available for Nop10.

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*Nop10^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Nop10^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Nop10^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Nop10^{tm446296(L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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