Tmed3 | transmembrane p24 trafficking protein 3
Physiological systems
17 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
16 No significant impact
7 Not tested
Data collections
Gene metrics:1Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| increased circulating iron level | 1 supporting dataset | Tmed3tm2b(EUCOMM)Hmgu | homozygote | Early adult | 4.2x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 50% (1/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Tmed3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmed3.
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| Tmed3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Tmed3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tmed3tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tmed3tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tmed3tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |