Crbn | cereblon
Physiological systems
22 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Digestive/alimentary Nervous system Vision/eye
19 No significant impact
2 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 3 supporting datasets | Crbntm1b(KOMP)Wtsi | homozygote | Early adult | 1.11x10-7 | ||
| abnormal cecum morphology | 1 supporting dataset | Crbntm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| absent optic nerve | 1 supporting dataset | Crbntm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal eye morphology | 1 supporting dataset | Crbntm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 50% (1/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
Human diseases caused by Crbn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Crbn.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Crbntm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Crbntm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Crbntm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Crbntm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Crbntm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell mouse |