Syncrip | synaptotagmin binding, cytoplasmic RNA interacting protein

GeneMGI:1891690Synonyms: 4632417O19Rik, 2610109K23Rik, +6 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased startle reflex	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.32x10^-13
hyperactivity	5 supporting datasets	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.99x10^-12
impaired glucose tolerance	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.56x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal behavior	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.18x10^-6
decreased thigmotaxis	2 supporting datasets	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.37x10^-6
decreased mean platelet volume	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.2x10^-5
increased bone mineral content	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.61x10^-5
abnormal auditory brainstem response	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.95x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Syncrip^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.15x10^-15

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Syncrip.

Associated images

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Histopathology

There is no histopathology data found for Syncrip.

IMPC related publications

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External links

No external links available for Syncrip.

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*Syncrip^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Syncrip^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Syncrip^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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