Prg4 | proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Growth/size/body region Behavior/neurological Skeleton
16 No significant impact
3 Not tested
Data collections
Gene metrics:9Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 5 supporting datasets | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 2.2x10-7 | ||
| decreased grip strength | 4 supporting datasets | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 1.6x10-23 | ||
| abnormal joint morphology | 1 supporting dataset | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 7.03x10-10 | ||
| abnormal skin morphology | 1 supporting dataset | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| improved glucose tolerance | 1 supporting dataset | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 4.12x10-5 | ||
| decreased body weight | 1 supporting dataset | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 8.11x10-7 | ||
| decreased exploration in new environment | 1 supporting dataset | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 2.23x10-5 | ||
| increased circulating potassium level | 1 supporting dataset | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 4.88x10-5 | ||
| increased anxiety-related response | 1 supporting dataset | Prg4em1(IMPC)Ccpcz | homozygote | Early adult | 2.18x10-7 |
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Human diseases caused by Prg4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prg4.
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| Prg4em1(IMPC)Ccpcz | Intra-exon deletion | | mouse |
| Prg4tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Prg4tm1.1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | ES Cell |