Srpk3 | serine/arginine-rich protein specific kinase 3

GeneMGI:1891338Synonyms: Stk23, Mssk1

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Digestive/alimentary Hematopoietic system Behavior/neurological Skeleton

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:146Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal cecum morphology	1 supporting dataset	Srpk3^{tm1b(KOMP)Wtsi}	hemizygote	Early adult	N/A ^*
decreased bone mineral density	1 supporting dataset	Srpk3^{tm1b(KOMP)Wtsi}	hemizygote	Early adult	1.01x10^-6
increased monocyte cell number	1 supporting dataset	Srpk3^{tm1b(KOMP)Wtsi}	hemizygote	Early adult	7.52x10^-5
decreased grip strength	1 supporting dataset	Srpk3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.73x10^-7
decreased grip strength	2 supporting datasets	Srpk3^{tm1b(KOMP)Wtsi}	hemizygote	Early adult	4.76x10^-13
megacolon	1 supporting dataset	Srpk3^{tm1b(KOMP)Wtsi}	hemizygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Srpk3.

Associated images

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Histopathology

There is no histopathology data found for Srpk3.

IMPC related publications

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External links

No external links available for Srpk3.

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*Srpk3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Srpk3^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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