Gabarapl2 | GABA type A receptor associated protein like 2

GeneMGI:1890602Synonyms: 0610012F20Rik, Gef2, +2 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system

14 No significant impact

4 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

decreased circulating serum albumin level1 supporting datasetGabarapl2tm1b(EUCOMM)HmguheterozygoteEarly adult1.91x10-5 
decreased hemoglobin content1 supporting datasetGabarapl2tm1b(EUCOMM)HmguheterozygoteEarly adult8.89x10-5 
decreased lymphocyte cell number1 supporting datasetGabarapl2tm1b(EUCOMM)HmguheterozygoteEarly adult3.63x10-5 
increased heart weight1 supporting datasetGabarapl2tm1b(EUCOMM)HmguheterozygoteEarly adult1.56x10-6 
increased monocyte cell number1 supporting datasetGabarapl2tm1b(EUCOMM)HmguheterozygoteEarly adult1.27x10-6 
increased neutrophil cell number1 supporting datasetGabarapl2tm1b(EUCOMM)HmguheterozygoteEarly adult2.79x10-11 
preweaning lethality, complete penetrance1 supporting datasetGabarapl2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a100% (2/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Gabarapl2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Gabarapl2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse

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