Gabarapl2 | GABA type A receptor associated protein like 2
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Mortality/aging Cardiovascular system
14 No significant impact
4 Not tested
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
decreased circulating serum albumin level | 1 supporting dataset | Gabarapl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.91x10-5 | ||
decreased hemoglobin content | 1 supporting dataset | Gabarapl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.89x10-5 | ||
decreased lymphocyte cell number | 1 supporting dataset | Gabarapl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.63x10-5 | ||
increased heart weight | 1 supporting dataset | Gabarapl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.56x10-6 | ||
increased monocyte cell number | 1 supporting dataset | Gabarapl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.27x10-6 | ||
increased neutrophil cell number | 1 supporting dataset | Gabarapl2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.79x10-11 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Gabarapl2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
External links
No external links available for Gabarapl2.
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Gabarapl2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Gabarapl2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |