Slc6a14 | solute carrier family 6 (neurotransmitter transporter), member 14
Physiological systems
21 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Reproductive system Hematopoietic system
19 No significant impact
3 Not tested
Data collections
Gene metrics:4Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal epididymis morphology | 1 supporting dataset | Slc6a14tm1b(KOMP)Wtsi | hemizygote | Early adult | N/A * | ||
| enlarged epididymis | 1 supporting dataset | Slc6a14tm1b(KOMP)Wtsi | hemizygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Slc6a14tm1b(KOMP)Wtsi | homozygote | Early adult | 1.48x10-5 | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Slc6a14tm1b(KOMP)Wtsi | homozygote | Early adult | 8.59x10-6 |
| | | | | | | | | | |
| adrenal gland | hemizygote | n/a | 0% (0/1) | 0.7% (4/570) |
| aorta | hemizygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood | hemizygote | n/a | n/a | 0% (0/17) |
| bone marrow | hemizygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | hemizygote | n/a | 0% (0/1) | 0.86% (5/579) |
| brainstem | hemizygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | hemizygote | n/a | 0% (0/1) | 0% (0/588) |
| cartilage tissue | hemizygote | n/a | n/a | 0.22% (1/454) |
| cecum | hemizygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | hemizygote | n/a | 0% (0/1) | 0.56% (3/532) |
Human diseases caused by Slc6a14 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc6a14.
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| Slc6a14tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Slc6a14tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Slc6a14tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |