Txnip | thioredoxin interacting protein
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Vision/eye Skeleton
14 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.65x10-8 | ||
| decreased bone mineral content | 2 supporting datasets | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.22x10-10 | ||
| decreased bone mineral density | 1 supporting dataset | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.53x10-5 | ||
| increased total body fat amount | 2 supporting datasets | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.33x10-11 | ||
| increased circulating phosphate level | 1 supporting dataset | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.68x10-7 | ||
| increased circulating triglyceride level | 1 supporting dataset | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.03x10-20 | ||
| abnormal retina morphology | 1 supporting dataset | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.61x10-7 | ||
| increased circulating calcium level | 1 supporting dataset | Txniptm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.52x10-8 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Txnip mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Txnip.
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| Txniptm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Txniptm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Txniptm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |