Dgke | diacylglycerol kinase, epsilon
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Behavior/neurological Skeleton
13 No significant impact
6 Not tested
Data collections
Gene metrics:5Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating creatinine level | 1 supporting dataset | Dgkeem1(IMPC)Tcp | homozygote | Early adult | 6.27x10-5 | ||
| abnormal testis morphology | 1 supporting dataset | Dgkeem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| hyperactivity | 1 supporting dataset | Dgkeem1(IMPC)Tcp | homozygote | Early adult | 1.06x10-5 | ||
| abnormal sternum morphology | 1 supporting dataset | Dgkeem1(IMPC)Tcp | homozygote | Early adult | N/A * |
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Human diseases caused by Dgke mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dgke.
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| Dgkeem1(IMPC)Tcp | Exon Deletion | | mouse |
| Dgketm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dgketm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dgketm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |