Ppbp | pro-platelet basic protein

GeneMGI:1888712Synonyms: TGB1, NAP-2-L1, +13 more

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system

17 No significant impact

3 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

increased spleen weight1 supporting datasetPpbptm1.1(KOMP)VlcghomozygoteEarly adult1.13x10-6 
increased neutrophil cell number2 supporting datasetsPpbptm1.1(KOMP)VlcghomozygoteEarly adult1.95x10-10 
increased circulating total protein level1 supporting datasetPpbptm1.1(KOMP)VlcghomozygoteEarly adult3.06x10-6 
decreased lymphocyte cell number1 supporting datasetPpbptm1.1(KOMP)VlcghomozygoteEarly adult5.81x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ppbptm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Ppbptm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Ppbptm459287(L1L2_GT1_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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