Aldh1a3 | aldehyde dehydrogenase family 1, subfamily A3
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging
16 No significant impact
4 Not tested
Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| microphthalmia | 1 supporting dataset | Aldh1a3tm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Aldh1a3tm1b(KOMP)Wtsi | heterozygote | Early adult | 6.5x10-5 | ||
| hyperactivity | 8 supporting datasets | Aldh1a3tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.01x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Aldh1a3tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | n/a | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Aldh1a3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Aldh1a3.
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| Aldh1a3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Aldh1a3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Aldh1a3tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Aldh1a3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Aldh1a3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Aldh1a3tm357331(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |