Crlf3 | cytokine receptor-like factor 3
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological
17 No significant impact
3 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| thrombocytopenia | 1 supporting dataset | Crlf3em1(IMPC)Wtsi | homozygote | Early adult | 9.54x10-13 | ||
| thrombocytopenia | 2 supporting datasets | Crlf3tm1a(KOMP)Wtsi | homozygote | Early adult | 4.54x10-10 | ||
| thrombocytopenia | 1 supporting dataset | Crlf3tm1b(KOMP)Wtsi | homozygote | Early adult | 2.53x10-7 | ||
| abnormal behavior | 1 supporting dataset | Crlf3tm1a(KOMP)Wtsi | homozygote | Early adult | 2.35x10-5 | ||
| decreased body weight | 1 supporting dataset | Crlf3tm1a(KOMP)Wtsi | homozygote | Early adult | 4.37x10-17 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Crlf3tm1b(KOMP)Wtsi | homozygote | Early adult | 1.93x10-7 | ||
| increased red blood cell distribution width | 1 supporting dataset | Crlf3em1(IMPC)Wtsi | homozygote | Early adult | 9.09x10-10 | ||
| tremors | 1 supporting dataset | Crlf3tm1a(KOMP)Wtsi | homozygote | Early adult | 8.93x10-5 | ||
| increased circulating iron level | 1 supporting dataset | Crlf3tm1a(KOMP)Wtsi | homozygote | Early adult | 9.48x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (3/3) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/3) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/3) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (3/3) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (3/3) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Crlf3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Crlf3.
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| Crlf3em1(IMPC)Wtsi | Deletion | | mouse |
| Crlf3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Crlf3tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Crlf3tm1c(KOMP)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Crlf3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Crlf3tm356713(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Crlf3tm38187(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |