Panx1 | pannexin 1
GeneMGI:1860055
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological
18 No significant impact
3 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| abnormal behavior | 1 supporting dataset | Panx1tm1b(KOMP)Wtsi | homozygote | Early adult | 6.85x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Panx1tm1b(KOMP)Wtsi | homozygote | Early adult | 2.42x10-7 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Panx1tm1b(KOMP)Wtsi | homozygote | Early adult | 3.15x10-7 | ||
| decreased thigmotaxis | 2 supporting datasets | Panx1tm1b(KOMP)Wtsi | homozygote | Early adult | 6.84x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 25% (1/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 50% (2/4) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
Human diseases caused by Panx1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Panx1.
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| Panx1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Panx1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Panx1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Panx1tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Panx1tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Panx1tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |