Wdr45 | WD repeat domain 45

GeneMGI:1859606Synonyms: Sfc19, C79260, +3 more

Physiological systems

16 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hearing/vestibular/ear Behavior/neurological Skeleton Cardiovascular system

10 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



hyperactivity	6 supporting datasets	Wdr45^em1(IMPC)J	homozygote	Late adult	1.24x10^-7
increased heart weight	1 supporting dataset	Wdr45^em1(IMPC)J	hemizygote	Late adult	8.33x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Wdr45^em1(IMPC)J	homozygote	Early adult	6.66x10^-15
hyperactivity	5 supporting datasets	Wdr45^em1(IMPC)J	hemizygote	Early adult	5.92x10^-8
hyperactivity	8 supporting datasets	Wdr45^em1(IMPC)J	hemizygote	Late adult	0
abnormal bone structure	1 supporting dataset	Wdr45^em1(IMPC)J	hemizygote	Early adult	3.1x10^-5
decreased bone mineral content	2 supporting datasets	Wdr45^em1(IMPC)J	homozygote	Early adult	3.77x10^-6
increased exploration in new environment	1 supporting dataset	Wdr45^em1(IMPC)J	homozygote	Late adult	9.11x10^-10
decreased bone mineral density	1 supporting dataset	Wdr45^em1(IMPC)J	homozygote	Early adult	1.47x10^-10
abnormal auditory brainstem response	1 supporting dataset	Wdr45^em1(IMPC)J	hemizygote	Early adult	1.22x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Wdr45.

Associated images

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Histopathology

There is no histopathology data found for Wdr45.

IMPC related publications

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External links

No external links available for Wdr45.

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*Wdr45^em1(IMPC)J*	Exon Deletion	‌	mouse
*Wdr45^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Wdr45^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Wdr45^{tm436189(L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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