Irf6 | interferon regulatory factor 6

GeneMGI:1859211Synonyms: E230028I05Rik

Physiological systems

15 / 24 physiological systems tested

1 Significantly impacted by the knock-out

 Homeostasis/metabolism

14 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:3Significant phenotypes
9Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating aspartate transaminase level1 supporting datasetIrf6em1(IMPC)WtsihomozygoteEarly adult3.63x10-6 
increased circulating creatine kinase level1 supporting datasetIrf6em1(IMPC)WtsihomozygoteEarly adult7.91x10-5 
increased circulating creatinine level1 supporting datasetIrf6em1(IMPC)WtsihomozygoteEarly adult1.37x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
Download data as:  

lacZ Expression

Associated images

Human diseases caused by Irf6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






Download data as:  

Histopathology

IMPC related publications

Loading...

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

Irf6em1(IMPC)WtsiPoint Mutationmouse
Irf6tm1(EGFP/cre/ERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Irf6tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Irf6tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter