Rnf10 | ring finger protein 10
GeneMGI:1859162
Physiological systems
24 / 24 physiological systems tested
14 Significantly impacted by the knock-out
Immune system Adipose tissue Growth/size/body region Hearing/vestibular/ear Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging
10 No significant impact
Gene metrics:67Significant phenotypes
0Associated diseases
Expression examined in:158Adult tissues
73Embryo tissues
| abnormal spleen morphology | 1 supporting dataset | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| decreased grip strength | 4 supporting datasets | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | 1.7x10-8 | ||
| decreased total retina thickness | 2 supporting datasets | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | 6.88x10-10 | ||
| decreased thigmotaxis | 2 supporting datasets | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | 3.82x10-5 | ||
| abnormal behavior | 2 supporting datasets | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | 1.87x10-14 | ||
| shortened ST segment | 1 supporting dataset | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | 1.41x10-5 | ||
| increased leukocyte cell number | 1 supporting dataset | Rnf10tm1a(KOMP)Wtsi | homozygote | Early adult | 4.49x10-5 | ||
| abnormal gait | 1 supporting dataset | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | 4.79x10-6 | ||
| decreased exploration in new environment | 1 supporting dataset | Rnf10em1(IMPC)J | homozygote | Late adult | 4.26x10-5 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Rnf10tm1b(KOMP)Wtsi | homozygote | Early adult | 3.59x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images Wholemount images | 76.19% (16/21) | 0.7% (4/570) |
| adrenal gland | homozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | homozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| aorta | heterozygote | Section images Wholemount images | 70% (14/20) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/3) | 0% (0/17) |
| blood vessel | heterozygote | n/a | 100% (4/4) | 0% (0/173) |
| bone | heterozygote | Wholemount images | 25% (2/8) | 0% (0/394) |
| bone | homozygote | Wholemount images | n/a | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/4) | 0% (0/22) |
| brain | heterozygote | Section images Wholemount images | 95.45% (21/22) | 0.86% (5/579) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rnf10.
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| Rnf10em1(IMPC)Bay | Exon Deletion | | mouse |
| Rnf10em1(IMPC)J | Exon Deletion | | mouse |
| Rnf10em1(IMPC)Mbp | Indel | | mouse |
| Rnf10tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Rnf10tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Rnf10tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Rnf10tm303169(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |