Mpp2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Physiological systems
18 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye
16 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
0Embryo tissues
| abnormal retina outer nuclear layer morphology | 1 supporting dataset | Mpp2tm1b(KOMP)Wtsi | homozygote | Early adult | 2.08x10-6 | ||
| decreased total retina thickness | 2 supporting datasets | Mpp2tm1b(KOMP)Wtsi | homozygote | Early adult | 7.16x10-9 | ||
| impaired glucose tolerance | 1 supporting dataset | Mpp2tm1b(KOMP)Wtsi | homozygote | Early adult | 2.58x10-5 | ||
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Mpp2tm1b(KOMP)Wtsi | homozygote | Early adult | 1.48x10-8 |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Mpp2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mpp2.
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| Mpp2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mpp2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |