Clpp | caseinolytic mitochondrial matrix peptidase proteolytic subunit
Physiological systems
18 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton
9 No significant impact
6 Not tested
Data collections
Gene metrics:39Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating bilirubin level | 1 supporting dataset | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.15x10-18 | ||
| increased monocyte cell number | 3 supporting datasets | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased bone mineral content | 1 supporting dataset | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.75x10-14 | ||
| increased hemoglobin content | 1 supporting dataset | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.06x10-6 | ||
| increased mature B cell number | 2 supporting datasets | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased KLRG1-positive NK cell number | 7 supporting datasets | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased CD4-positive NK T cell number | 1 supporting dataset | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased red blood cell distribution width | 1 supporting dataset | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.74x10-6 | ||
| decreased lean body mass | 1 supporting dataset | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.3x10-7 | ||
| thrombocytopenia | 1 supporting dataset | Clpptm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.18x10-6 |
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Human diseases caused by Clpp mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Clpp.
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| Clpptm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Clpptm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |