Vti1a | vesicle transport through interaction with t-SNAREs 1A

GeneMGI:1855699Synonyms: 1110014F16Rik, 1110018K19Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Behavior/neurological Mortality/aging

14 No significant impact

3 Not tested

Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

abnormal auditory brainstem response1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult3.73x10-6 
abnormal behavior1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult7.35x10-14 
abnormal epididymis morphology1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal testis morphology1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
decreased body length1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult6.72x10-8 
decreased fasting circulating glucose level1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult3.91x10-7 
decreased thigmotaxis2 supporting datasetsVti1atm1.1(KOMP)VlcghomozygoteEarly adult7.23x10-14 
enlarged epididymis1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
hyperactivity4 supporting datasetsVti1atm1.1(KOMP)VlcghomozygoteEarly adult3.83x10-20 
increased circulating alkaline phosphatase level1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult1.44x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

  • ...
adrenal glandheterozygoteSection images
100% (2/2)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
bloodheterozygoteSection images
100% (2/2)0% (0/17)
bone marrowheterozygoteSection images
100% (2/2)0% (0/22)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/an/a0.41% (2/490)
brown adipose tissueheterozygoteSection images
100% (2/2)0% (0/588)
cartilage tissueheterozygoten/an/a0.22% (1/454)
cecumheterozygoteSection images
100% (2/2)7.75% (22/284)
cerebellumheterozygoteSection images
100% (2/2)0.56% (3/532)
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Human diseases caused by Vti1a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Vti1atm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Vti1atm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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