Vti1a | vesicle transport through interaction with t-SNAREs 1A
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Behavior/neurological Mortality/aging
14 No significant impact
3 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
abnormal auditory brainstem response | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | 3.73x10-6 | ||
abnormal behavior | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | 7.35x10-14 | ||
abnormal epididymis morphology | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
abnormal testis morphology | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
decreased body length | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | 6.72x10-8 | ||
decreased fasting circulating glucose level | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | 3.91x10-7 | ||
decreased thigmotaxis | 2 supporting datasets | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | 7.23x10-14 | ||
enlarged epididymis | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
hyperactivity | 4 supporting datasets | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | 3.83x10-20 | ||
increased circulating alkaline phosphatase level | 1 supporting dataset | Vti1atm1.1(KOMP)Vlcg | homozygote | Early adult | 1.44x10-8 |
| | | | | | | | | |
adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
blood | heterozygote | Section images | 100% (2/2) | 0% (0/17) |
bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Vti1a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Vti1a.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.