Fbxo15 | F-box protein 15
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Immune system Growth/size/body region Vision/eye Hematopoietic system
13 No significant impact
7 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Fbxo15em1(IMPC)Marc | homozygote | Early adult | 5.37x10-5 | ||
| increased eosinophil cell number | 2 supporting datasets | Fbxo15em1(IMPC)Marc | homozygote | Early adult | 2.03x10-12 | ||
| increased basophil cell number | 2 supporting datasets | Fbxo15em1(IMPC)Marc | homozygote | Early adult | 4.34x10-7 | ||
| increased leukocyte cell number | 1 supporting dataset | Fbxo15em1(IMPC)Marc | homozygote | Early adult | 5.94x10-9 | ||
| increased neutrophil cell number | 2 supporting datasets | Fbxo15em1(IMPC)Marc | homozygote | Early adult | 3.23x10-21 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Fbxo15em1(IMPC)Marc | homozygote | Early adult | 1.41x10-13 | ||
| enlarged spleen | 1 supporting dataset | Fbxo15em1(IMPC)Marc | homozygote | Early adult | N/A * |
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Human diseases caused by Fbxo15 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fbxo15.
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| Fbxo15em1(IMPC)Marc | Deletion | | mouse |
| Fbxo15tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fbxo15tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Fbxo15tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |