Gnl3 | guanine nucleotide binding protein nucleolar 3

GeneMGI:1353651Synonyms: nucleostemin, NS

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating insulin level	1 supporting dataset	Gnl3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.12x10^-7
preweaning lethality, incomplete penetrance	1 supporting dataset	Gnl3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gnl3.

Associated images

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Histopathology

There is no histopathology data found for Gnl3.

IMPC related publications

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External links

No external links available for Gnl3.

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*Gnl3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Gnl3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	ES Cell mouse
*Gnl3^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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