Pdlim4 | PDZ and LIM domain 4
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Endocrine/exocrine gland Limbs/digits/tail Behavior/neurological Skeleton
13 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased locomotor activity | 1 supporting dataset | Pdlim4em1(IMPC)Ics | homozygote | Early adult | 7.44x10-6 | ||
| short tibia | 2 supporting datasets | Pdlim4em1(IMPC)Ics | homozygote | Early adult | 3.34x10-5 | ||
| increased anxiety-related response | 1 supporting dataset | Pdlim4em1(IMPC)Ics | homozygote | Early adult | 2.9x10-5 | ||
| abnormal pancreas morphology | 1 supporting dataset | Pdlim4em1(IMPC)Ics | homozygote | Early adult | N/A * | ||
| abnormal behavior | 1 supporting dataset | Pdlim4em1(IMPC)Ics | homozygote | Early adult | 4.47x10-5 | ||
| increased thigmotaxis | 2 supporting datasets | Pdlim4em1(IMPC)Ics | homozygote | Early adult | 4.47x10-5 | ||
| improved glucose tolerance | 1 supporting dataset | Pdlim4em1(IMPC)Ics | homozygote | Early adult | 5.69x10-6 | ||
| decreased circulating glucose level | 1 supporting dataset | Pdlim4em1(IMPC)Ics | homozygote | Early adult | 9x10-5 |
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Human diseases caused by Pdlim4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pdlim4.
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| Pdlim4em1(IMPC)Ics | Exon Deletion | | mouse |
| Pdlim4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pdlim4tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Pdlim4tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pdlim4tm301216(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Pdlim4tm37806(pL1L2_GT2_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |