Nr1h4 | nuclear receptor subfamily 1, group H, member 4

GeneMGI:1352464Synonyms: Fxr, RIP14, +3 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Hematopoietic system Behavior/neurological

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased startle reflex	5 supporting datasets	Nr1h4^Nr1h4	homozygote	Early adult	9.21x10^-6
increased circulating HDL cholesterol level	1 supporting dataset	Nr1h4^Nr1h4	homozygote	Early adult	5.25x10^-12
increased lactate dehydrogenase level	1 supporting dataset	Nr1h4^Nr1h4	homozygote	Early adult	2.12x10^-6
increased circulating triglyceride level	2 supporting datasets	Nr1h4^Nr1h4	homozygote	Early adult	3.07x10^-13
increased circulating aspartate transaminase level	1 supporting dataset	Nr1h4^Nr1h4	homozygote	Early adult	6.53x10^-22
decreased mean corpuscular volume	1 supporting dataset	Nr1h4^Nr1h4	homozygote	Early adult	6.76x10^-7
increased circulating cholesterol level	2 supporting datasets	Nr1h4^Nr1h4	homozygote	Early adult	1.87x10^-22
decreased locomotor activity	1 supporting dataset	Nr1h4^Nr1h4	homozygote	Early adult	2.02x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Nr1h4^Nr1h4	homozygote	Early adult	1.15x10^-22
decreased circulating serum albumin level	1 supporting dataset	Nr1h4^Nr1h4	homozygote	Early adult	8.14x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nr1h4.

Associated images

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Histopathology

There is no histopathology data found for Nr1h4.

IMPC related publications

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External links

No external links available for Nr1h4.

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*Nr1h4^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Nr1h4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Nr1h4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Nr1h4^{tm41590(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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