Prmt5 | protein arginine N-methyltransferase 5

GeneMGI:1351645Synonyms: Skb1, Jak-binding protein 1, +1 more

Physiological systems

20 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Mortality/aging

18 No significant impact

4 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetPrmt5tm2a(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased circulating iron level1 supporting datasetPrmt5tm2a(EUCOMM)WtsiheterozygoteEarly adult1.5x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Prmt5tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Prmt5tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Prmt5tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Prmt5tm2b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Prmt5tm2c(EUCOMM)WtsiWild type floxed exon (post-Flp)mouse
Prmt5tm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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