Dguok | deoxyguanosine kinase
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Reproductive system Adipose tissue Growth/size/body region Behavior/neurological Skeleton
12 No significant impact
7 Not tested
Data collections
Gene metrics:9Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased bone mineral density | 1 supporting dataset | Dguokem1(IMPC)J | homozygote | Early adult | 8.64x10-8 | ||
| abnormal locomotor behavior | 1 supporting dataset | Dguokem1(IMPC)J | homozygote | Early adult | 6.99x10-6 | ||
| increased total body fat amount | 1 supporting dataset | Dguokem1(IMPC)J | homozygote | Early adult | 6.49x10-6 | ||
| increased grip strength | 2 supporting datasets | Dguokem1(IMPC)J | homozygote | Early adult | 1.1x10-21 | ||
| increased bone mineral content | 1 supporting dataset | Dguokem1(IMPC)J | homozygote | Early adult | 5.04x10-7 | ||
| decreased locomotor activity | 6 supporting datasets | Dguokem1(IMPC)J | homozygote | Early adult | 1.79x10-9 | ||
| decreased lean body mass | 1 supporting dataset | Dguokem1(IMPC)J | homozygote | Early adult | 9.49x10-6 | ||
| decreased exploration in new environment | 1 supporting dataset | Dguokem1(IMPC)J | homozygote | Early adult | 9.59x10-5 | ||
| female infertility | 1 supporting dataset | Dguokem1(IMPC)J | homozygote | Early adult | N/A * |
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Human diseases caused by Dguok mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dguok.
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| Dguokem1(IMPC)J | Exon Deletion | | mouse |
| Dguoktm43098(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |