Dguok | deoxyguanosine kinase

GeneMGI:1351602Synonyms: dGK

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Reproductive system Adipose tissue Growth/size/body region Behavior/neurological Skeleton

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:9Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased bone mineral density1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult8.64x10-8 
abnormal locomotor behavior1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult6.99x10-6 
increased total body fat amount1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult6.49x10-6 
increased grip strength2 supporting datasetsDguokem1(IMPC)JhomozygoteEarly adult1.1x10-21 
increased bone mineral content1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult5.04x10-7 
decreased locomotor activity6 supporting datasetsDguokem1(IMPC)JhomozygoteEarly adult1.79x10-9 
decreased lean body mass1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult9.49x10-6 
decreased exploration in new environment1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adult9.59x10-5 
female infertility1 supporting datasetDguokem1(IMPC)JhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Dguok mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Dguokem1(IMPC)JExon Deletionmouse
Dguoktm43098(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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