Cops7a | COP9 signalosome subunit 7A
Physiological systems
18 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system
8 No significant impact
6 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased thigmotaxis | 2 supporting datasets | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 7.15x10-8 | ||
| increased heart weight | 2 supporting datasets | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 1.05x10-5 | ||
| abnormal eye morphology | 2 supporting datasets | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| improved glucose tolerance | 1 supporting dataset | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 3.95x10-5 | ||
| hyperactivity | 1 supporting dataset | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 2.14x10-7 | ||
| increased monocyte cell number | 1 supporting dataset | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 5.21x10-5 | ||
| abnormal urinary bladder morphology | 1 supporting dataset | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| abnormal behavior | 1 supporting dataset | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 8.34x10-8 | ||
| decreased blood urea nitrogen level | 1 supporting dataset | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 4.81x10-7 | ||
| decreased prepulse inhibition | 1 supporting dataset | Cops7atm1b(KOMP)Mbp | homozygote | Early adult | 8.82x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 50% (1/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
Human diseases caused by Cops7a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cops7a.
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| Cops7atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Cops7atm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cops7atm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Cops7atm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |