Cops7a | COP9 signalosome subunit 7A

GeneMGI:1349400Synonyms: COP9 complex S7a, D6Ertd35e

Physiological systems

18 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

8 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased thigmotaxis	2 supporting datasets	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	7.15x10^-8
increased heart weight	2 supporting datasets	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	1.05x10^-5
abnormal eye morphology	2 supporting datasets	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
improved glucose tolerance	1 supporting dataset	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	3.95x10^-5
hyperactivity	1 supporting dataset	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	2.14x10^-7
increased monocyte cell number	1 supporting dataset	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	5.21x10^-5
abnormal urinary bladder morphology	1 supporting dataset	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	N/A ^*
abnormal behavior	1 supporting dataset	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	8.34x10^-8
decreased blood urea nitrogen level	1 supporting dataset	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	4.81x10^-7
decreased prepulse inhibition	1 supporting dataset	Cops7a^{tm1b(KOMP)Mbp}	homozygote	Early adult	8.82x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cops7a.

Associated images

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Histopathology

There is no histopathology data found for Cops7a.

IMPC related publications

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External links

No external links available for Cops7a.

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*Cops7a^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cops7a^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cops7a^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Cops7a^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	es cell

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