Pla2g10 | phospholipase A2, group X
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
16 No significant impact
2 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| abnormal lens morphology | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.03x10-9 | ||
| cataract | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.76x10-8 | ||
| decreased heart rate | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.93x10-6 | ||
| increased heart rate variability | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.83x10-9 | ||
| cardiovascular system phenotype | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.66x10-22 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Pla2g10tm1a(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased mature B cell number | 1 supporting dataset | Pla2g10tm1a(EUCOMM)Hmgu | heterozygote | Early adult | 6.98x10-5 | ||
| prolonged QT interval | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.2x10-14 | ||
| abnormal QT variability | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.99x10-18 | ||
| prolonged RR interval | 1 supporting dataset | Pla2g10tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.17x10-26 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/1) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/1) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/1) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
External links
No external links available for Pla2g10.
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| Pla2g10tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Pla2g10tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pla2g10tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pla2g10tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pla2g10tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |