Slc7a11 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

GeneMGI:1347355Synonyms: xCT, x<c>, +3 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Vision/eye Hearing/vestibular/ear

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal auditory brainstem response2 supporting datasetsSlc7a11tm1b(EUCOMM)WtsihomozygoteEarly adult7.8x10-5 
abnormal vitreous body morphology2 supporting datasetsSlc7a11tm1b(EUCOMM)WtsihomozygoteEarly adult2.18x10-6 
increased circulating glucose level1 supporting datasetSlc7a11tm1b(EUCOMM)WtsihomozygoteEarly adult3.13x10-5 
abnormal optic disk morphology1 supporting datasetSlc7a11tm1b(EUCOMM)WtsihomozygoteEarly adult3.71x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Slc7a11tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Slc7a11tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Slc7a11tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Slc7a11tm40212(L1L2_gt2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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