Fto | FTO alpha-ketoglutarate dependent dioxygenase
GeneMGI:1347093
Physiological systems
20 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
19 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
3Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating alanine transaminase level | 1 supporting dataset | Ftotm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.76x10-6 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Ftotm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.09x10-5 | ||
| decreased circulating iron level | 1 supporting dataset | Ftotm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.21x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (1/1) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Fto mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Fto.
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| Ftotm1(EGFP/cre/ERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Ftotm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ftotm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ftotm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |