Esrra | estrogen related receptor, alpha

GeneMGI:1346831Synonyms: ERRalpha, Nr3b1, +2 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Cardiovascular system

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin concentration	1 supporting dataset	Esrra^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.28x10^-5
decreased vertical activity	1 supporting dataset	Esrra^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.42x10^-6
hyperactivity	1 supporting dataset	Esrra^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.77x10^-5
shortened PQ interval	1 supporting dataset	Esrra^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.64x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Esrra^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.26x10^-11
increased grip strength	2 supporting datasets	Esrra^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.02x10^-6
increased startle reflex	1 supporting dataset	Esrra^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.21x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Esrra.

Associated images

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Histopathology

There is no histopathology data found for Esrra.

IMPC related publications

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External links

No external links available for Esrra.

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*Esrra^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Esrra^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Esrra^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Esrra^{tm457105(L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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