Scamp2 | secretory carrier membrane protein 2

GeneMGI:1346518Synonyms: Sc2

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Hearing/vestibular/ear Vision/eye Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal auditory brainstem response8 supporting datasetsScamp2em1(IMPC)JhomozygoteEarly adult6.67x10-7 
increased circulating total protein level1 supporting datasetScamp2em1(IMPC)JhomozygoteLate adult2.75x10-6 
decreased fasting circulating glucose level1 supporting datasetScamp2em1(IMPC)JhomozygoteEarly adult4.13x10-9 
decreased grip strength1 supporting datasetScamp2em1(IMPC)JhomozygoteLate adult6.13x10-5 
sclerocornea1 supporting datasetScamp2em1(IMPC)JhomozygoteLate adult9.45x10-5 
cataract1 supporting datasetScamp2em1(IMPC)JhomozygoteEarly adult1x10-5 
decreased startle reflex1 supporting datasetScamp2em1(IMPC)JhomozygoteEarly adult4.96x10-7 
abnormal startle reflex1 supporting datasetScamp2em1(IMPC)JhomozygoteLate adult1.94x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Human diseases caused by Scamp2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Scamp2em1(IMPC)JExon Deletionmouse
Scamp2tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Scamp2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Scamp2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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