Bves | blood vessel epicardial substance
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Adipose tissue Behavior/neurological Skeleton Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| improved glucose tolerance | 1 supporting dataset | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | 1.21x10-6 | ||
| decreased locomotor activity | 4 supporting datasets | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | 5.81x10-6 | ||
| abnormal skin morphology | 1 supporting dataset | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased bone mineral content | 1 supporting dataset | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | 1.2x10-15 | ||
| decreased total body fat amount | 1 supporting dataset | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | 8.24x10-5 | ||
| increased grip strength | 1 supporting dataset | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | 1.41x10-5 | ||
| abnormal vocalization | 1 supporting dataset | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | 1.11x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Bvestm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 50% (1/2) | 0.56% (3/532) |
Human diseases caused by Bves mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Bves.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Bvestm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Bvestm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Bvestm92176(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |