Sufu | SUFU negative regulator of hedgehog signaling

GeneMGI:1345643Synonyms: Su(Fu), 2810026F04Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Immune system Integument Adipose tissue Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Liver/biliary system Digestive/alimentary Behavior/neurological Mortality/aging Cardiovascular system

7 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

11Associated diseases

Expression examined in:41Adult tissues

30Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal neural tube closure	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal placenta size	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Sufu^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
cardiovascular system phenotype	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.9x10^-5
pale liver	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal forebrain development	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal midbrain development	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal hindbrain development	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E9.5	N/A ^*
abnormal limb bud morphology	1 supporting dataset	Sufu^{tm1b(KOMP)Wtsi}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sufu.

Associated images

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Histopathology

There is no histopathology data found for Sufu.

IMPC related publications

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External links

No external links available for Sufu.

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*Sufu^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Sufu^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Sufu^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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