Amfr | autocrine motility factor receptor
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Behavior/neurological Skeleton
15 No significant impact
5 Not tested
Data collections
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating total protein level | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | homozygote | Early adult | 1.82x10-7 | ||
| increased lean body mass | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | homozygote | Early adult | 1x10-5 | ||
| increased bone mineral density | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | homozygote | Early adult | 5.91x10-7 | ||
| abnormal behavior | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | homozygote | Early adult | 3.89x10-5 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | homozygote | Early adult | 6.23x10-6 | ||
| decreased circulating alanine transaminase level | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | homozygote | Early adult | 9.01x10-7 | ||
| abnormal behavior | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | heterozygote | Early adult | 1.03x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | heterozygote | Early adult | 2.41x10-5 | ||
| decreased lactate dehydrogenase level | 1 supporting dataset | Amfrtm1a(KOMP)Wtsi | homozygote | Early adult | 1.31x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 50% (1/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (1/1) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Amfr mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Amfr.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Amfrem1(IMPC)Wtsi | Exon Deletion | | mouse |
| Amfrtm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Amfrtm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |