Edar | ectodysplasin-A receptor
GeneMGI:1343498
Physiological systems
21 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Nervous system Mortality/aging
19 No significant impact
3 Not tested
Data collections
Gene metrics:2Significant phenotypes
5Associated diseases
Expression examined in:42Adult tissues
0Embryo tissues
| decreased prepulse inhibition | 1 supporting dataset | Edartm1b(KOMP)Wtsi | heterozygote | Early adult | 7.73x10-6 | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Edartm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | Section images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
| eye | heterozygote | n/a | 0% (0/2) | 0% (0/335) |
Human diseases caused by Edar mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Edar.
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| Edartm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Edartm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Edartm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Edartm43507(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |