Snf8 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
Physiological systems
21 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
18 No significant impact
3 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating free fatty acids level | 1 supporting dataset | Snf8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.56x10-6 | ||
| increased lactate dehydrogenase level | 1 supporting dataset | Snf8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.57x10-5 | ||
| abnormal tail movements | 1 supporting dataset | Snf8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.17x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Snf8tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/1) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Snf8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Snf8.
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| Snf8tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Snf8tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Snf8tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Snf8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Snf8tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Snf8tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Snf8tm76(L1L2_gt0_Del_LacZ) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Snf8tm76(pL1L2_GT0_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Snf8tm76(pL1L2_frt15_BetactinBSD_frt14_neo_Rox) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |