Trank1 | tetratricopeptide repeat and ankyrin repeat containing 1
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Hematopoietic system Behavior/neurological
12 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal vocalization | 1 supporting dataset | Trank1em1(IMPC)J | homozygote | Early adult | 2.42x10-10 | ||
| decreased circulating creatinine level | 1 supporting dataset | Trank1em1(IMPC)J | homozygote | Early adult | 2.74x10-6 | ||
| decreased hemoglobin content | 1 supporting dataset | Trank1em1(IMPC)J | homozygote | Early adult | 9.26x10-11 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Trank1em1(IMPC)J | homozygote | Early adult | 6.5x10-12 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Trank1em1(IMPC)J | homozygote | Early adult | 1.05x10-11 | ||
| decreased hematocrit | 1 supporting dataset | Trank1em1(IMPC)J | homozygote | Early adult | 4.07x10-13 |
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Human diseases caused by Trank1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Trank1.
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| Trank1em1(IMPC)J | Exon Deletion | | mouse |
| Trank1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Trank1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |