P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye
18 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
1Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| decreased circulating glycerol level | 1 supporting dataset | P2rx7tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.41x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | P2rx7tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.44x10-5 | ||
| cataract | 1 supporting dataset | P2rx7tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.41x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by P2rx7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for P2rx7.
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| P2rx7tm1(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| P2rx7tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| P2rx7tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| P2rx7tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| P2rx7tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |