Myh8 | myosin, heavy polypeptide 8, skeletal muscle, perinatal
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Hematopoietic system Skeleton Mortality/aging Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Myh8em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Myh8em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| abnormal sternum morphology | 1 supporting dataset | Myh8em1(IMPC)Tcp | heterozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Myh8em1(IMPC)Tcp | homozygote | E15.5 | N/A * | ||
| decreased hematocrit | 1 supporting dataset | Myh8em1(IMPC)Tcp | heterozygote | Early adult | 2.35x10-7 | ||
| enlarged urinary bladder | 1 supporting dataset | Myh8em1(IMPC)Tcp | heterozygote | Early adult | N/A * |
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Human diseases caused by Myh8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Myh8.
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| Myh8em1(IMPC)Tcp | Exon Deletion | | mouse |
| Myh8tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Myh8tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Myh8tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Myh8tm2(EGFP_CreERT2)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Myh8tm2e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |