Padi4 | peptidyl arginine deiminase, type IV
Physiological systems
20 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system Renal/urinary system
10 No significant impact
4 Not tested
Data collections
Gene metrics:20Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal liver morphology | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal vitreous body morphology | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | 6.6x10-5 | ||
| enlarged heart | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal spleen morphology | 2 supporting datasets | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged spleen | 2 supporting datasets | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| enlarged lymph nodes | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Padi4em1(IMPC)Mbp | homozygote | Late adult | N/A * |
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Human diseases caused by Padi4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Padi4.
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| Padi4em1(IMPC)Mbp | Exon Deletion | | mouse |
| Padi4tm560(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Padi4tm560(L1L2_gt2) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |