Bmp10 | bone morphogenetic protein 10
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Bmp10tm3b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Bmp10tm3b(EUCOMM)Hmgu | heterozygote | Early adult | 2.69x10-7 | ||
| improved glucose tolerance | 2 supporting datasets | Bmp10tm3b(EUCOMM)Hmgu | heterozygote | Early adult | 5.61x10-8 | ||
| decreased circulating creatinine level | 1 supporting dataset | Bmp10tm3b(EUCOMM)Hmgu | heterozygote | Early adult | 2.55x10-7 |
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Human diseases caused by Bmp10 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Bmp10.
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| Bmp10tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Bmp10tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Bmp10tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Bmp10tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Bmp10tm3a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Bmp10tm3b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |