Gdap1 | ganglioside-induced differentiation-associated-protein 1
GeneMGI:1338002
Physiological systems
21 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Hematopoietic system
16 No significant impact
3 Not tested
Data collections
Gene metrics:8Significant phenotypes
9Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| small adrenal glands | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal adrenal gland morphology | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal epididymis morphology | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| enlarged epididymis | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| small thymus | 1 supporting dataset | Gdap1tm2b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/1) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Gdap1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gdap1.
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| Gdap1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gdap1tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Gdap1tm2b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Gdap1tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Gdap1tm3a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gdap1tm3e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |