Gdap2 | ganglioside-induced differentiation-associated-protein 2
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton
11 No significant impact
7 Not tested
Data collections
Gene metrics:9Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased circulating fructosamine level | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 1.32x10-8 | ||
| decreased circulating amylase level | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 1.85x10-5 | ||
| increased bone mineral density | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 6.97x10-5 | ||
| absent pinna reflex | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 1.99x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 1.68x10-7 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 4.01x10-9 | ||
| increased lean body mass | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 4.29x10-6 | ||
| thrombocytosis | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 6.82x10-6 | ||
| decreased circulating thyroxine level | 1 supporting dataset | Gdap2em1(IMPC)Wtsi | homozygote | Early adult | 4.52x10-7 |
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Human diseases caused by Gdap2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Gdap2.
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| Gdap2em1(IMPC)Wtsi | Deletion | | mouse |
| Gdap2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Gdap2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Gdap2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Gdap2tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Gdap2tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |