Hpca | hippocalcin
GeneMGI:1336200
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Skeleton
16 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| hyperactivity | 7 supporting datasets | Hpcaem1(IMPC)H | homozygote | Late adult | 6.47x10-15 | ||
| hyperactivity | 7 supporting datasets | Hpcaem1(IMPC)H | homozygote | Early adult | 9.81x10-24 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Hpcaem1(IMPC)H | homozygote | Late adult | 1.86x10-7 | ||
| increased grip strength | 1 supporting dataset | Hpcaem1(IMPC)H | homozygote | Late adult | 8.76x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Hpcaem1(IMPC)H | homozygote | Late adult | 4.85x10-9 | ||
| impaired glucose tolerance | 1 supporting dataset | Hpcaem1(IMPC)H | homozygote | Early adult | 3.98x10-5 | ||
| decreased freezing behavior | 1 supporting dataset | Hpcaem1(IMPC)H | homozygote | Late adult | 8.97x10-5 | ||
| abnormal locomotor behavior | 1 supporting dataset | Hpcaem1(IMPC)H | homozygote | Early adult | 5.25x10-5 |
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Human diseases caused by Hpca mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hpca.
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| Hpcaem1(IMPC)H | Exon Deletion | | mouse |
| Hpcaem2(IMPC)H | Exon Deletion | | mouse |
| Hpcatm465143(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |