Prkaa2 | protein kinase, AMP-activated, alpha 2 catalytic subunit
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological
12 No significant impact
7 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased mean platelet volume | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.42x10-6 | ||
| decreased circulating fructosamine level | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.12x10-7 | ||
| decreased exploration in new environment | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.53x10-5 | ||
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.72x10-5 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.09x10-7 | ||
| increased circulating creatine kinase level | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.07x10-5 | ||
| enlarged spleen | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased circulating serum albumin level | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.62x10-6 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.67x10-42 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Prkaa2tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.83x10-23 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/1) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 50% (1/2) | 1.67% (7/419) |
Human diseases caused by Prkaa2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prkaa2.
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| Prkaa2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Prkaa2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Prkaa2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |